EO 91100
The final boss is on floor 99. Floor 100 is just a long run to the finish. Make sure you have time for this as it takes about 1m5s with 2 sprints  one at the start and another just before the finish.
Enemy Details
Orthos Mining Drone
Ability  Potency  Effect 

Run Amok  100  instant; inflicts knockback; used 4 times in a row 
Aetherochemical Cannon  ?  huge 180 degree AoE with late telegraph  get behind 
Orthosystem α
Ability  Potency  Effect 

Aetherochemical Laser α  ?  huge conal AoE with late telegraph  get behind 
Orthosystem γ
Ability  Potency  Effect 

High Voltage  ?  huge pointblank AoE with late telegraph  get out; can be interrupted 
Repelling Cannons  ?  pointblank AoE with late telegraph  get out 
Ring Cannon  4500  donut AoE with late telegraph  get in 
Notes
 Can only be slowed with Arm's Length if transfigured via Pomander of Witching since it doesn't normally do melee autoattacks
Orthodrone
Ability  Potency  Effect 

Autocannons  ?  telegraphed huge line AoE 
Selfdetonate  5000  untelegraphed pointblank AoE used AFTER DEATH  get away 
Notes
 Can only be slowed with Arm's Length if transfigured via Pomander of Witching since it doesn't normally do melee autoattacks
Orthos Motherbit
Ability  Potency  Effect 

Allagan Gravity  ?  telegraphed circle AoE 
Citadel Buster  ?  line AoE with late telegraph  get to side or behind 
Notes
 Can only be slowed with Arm's Length if transfigured via Pomander of Witching since it doesn't normally do melee autoattacks
Orthos Zaghnal
Ability  Potency  Effect 

Beastly Roar  ?  huge pointblank AoE with late telegraph; only used out of combat 
Pounce Errant  100  circle AoE gap closer on marked player 
Servomechanical Orthotaur
Ability  Potency  Effect 

32tonze Swipe  ?  large conal AoE with late telegraph  get to side or behind 
Zoom In  100  instant gap closer 
128tonze Swing  ?  pointblank AoE with late telegraph  get out 
Orthos Sphinx
Ability  Potency  Effect 

Naked Soul  ?  conal gaze AoE 
Swinge  ?  huge conal AoE with late telegraph  get to side or behind; used immediately after Naked Soul 
Orthos Mithridates
Ability  Potency  Effect 

Laserblade  ?  huge 270 degree frontal AoE with late telegraph  get behind 
Thunder Beam  120  instant 
Servomechanical Orthochimera
Ability  Potency  Effect 

Feral Lunge  80  instant gap closer 
The Ram's Voice  ?  untelegraphed pointblank AoE  get out 
The Dragon's Voice  3500  untelegraphed donut AoE  get in 
The Dragon's Breath  ?  conal AoE to the front and left with late telegraph  get behind 
Engulfing Ice  ?  conal AoE to the front and right with late telegraph  get behind 
Scorpion Sting  ?  backward conal AoE with quick cast  get in front; used when someone is close behind 
Orthos Durga
Ability  Potency  Effect 

Diffusion Ray  ?  telegraphed huge conal AoE 
Brainjack  ?  inflicts confused (3s) 
Thermobaric Charge  ?  telegraphed circle AoE; used immediately after Brainjack, but there's plenty of time to escape after confused wears off 
Orthos Fitter
Ability  Potency  Effect 

Allagan Fear  ?  360 degree gaze AoE 
Unholy  2000  untelegraphed huge pointblank AoE; only used out of combat 
Notes
 As of patch 6.35, a bug in the game sometimes causes the Unholy cast bar and effect to be hidden when the Lethargy protomander is active. Be VERY CAREFUL when using Lethargy on these floors!
Orthonaught
Ability  Potency  Effect 

Rotoswipe  ?  conal AoE with late telegraph  get behind or away 
Steam Clean  ?  grants physical damage up to self 
Mimic
Ability  Potency  Effect 

Infatuation  n/a  inflicts pox (magic DoT potency 5, 10m); can be interrupted 
Deathtrap  4000  telegraphed pointblank AoE 
Notes
 Sometimes found in gold chests
 Protomander of Alteration transforms all enemies in a random room on the next floor into either mimics or mandragoras
DemiCochma
Ability  Potency  Effect 

Empty Hand (?)  100  instant; also grants permanent stacking vulnerability down (10% per stack) to self 
Genesis (?)  ?  huge pointblank AoE sacrificial enrage; used at critical HP 
Notes
 Dread beast
 Immune to knockback, which means it will not die to the Rotosmash ability from the Protomander of Dread
 Grants 30m vulnerability down buff (10%) upon defeat
Lamia Queen
Ability  Potency  Effect 

Circle of Flame (?)  80  instant circle AoE; also grants permanent stacking HP regeneration to self 
Circle Blade  ?  telegraphed pointblank AoE 
Petrifaction  n/a  huge 360 degree gaze inflicting stone curse (1m); also affects enemies. Used at critical health (such as after Storms or landmine) 
Notes
 Dread beast
 Immune to knockback, which means it will not die to the Rotosmash ability from the Protomander of Dread
 Grants 30m regen buff upon defeat
Meracydian Clone
Ability  Potency  Effect 

Hard Thrust (?)  90  instant 
Berserk  n/a  probably grants damage up to self; can be interrupted 
Allagan Meteor  ?  huge (20y) pointblank AoE enrage; used below 40% HP 
Notes
 Dread beast
 Immune to knockback, which means it will not die to the Rotosmash ability from the Protomander of Dread
 Grants 30m damage up buff (10%) upon defeat
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Enemies
1  2  3  4  5  6  7  8  9  !  Name  Warnings  HP  AA  Vulnerabilities  

Orthos Mining Drone  420K  4864  
Orthosystem α  336K  8200  
Orthosystem γ  336K  8200  
Orthodrone  319K  7787  
Orthos Motherbit  336K  10K  
Orthos Zaghnal  354K  7193  
Servomechanical Orthotaur  354K  11K  
Orthos Sphinx  354K  11K  
Orthos Mithridates  336K  7181  
Servomechanical Orthochimera  354K  11K  
Orthos Durga  354K  8566  
Orthos Fitter  354K  ?  
Orthonaught  354K  ?  
Mimic  466K  15K  
DemiCochma  1400K  ?  
Lamia Queen  1400K  ?  
Meracydian Clone  1400K  ? 
Boss: Excalibur
Ability  Potency  Effect 

Paradoxum  400  roomwide AoE; grants Soul of Ice or Soul of Fire to each player; if there are Caliburni swords, this imbues one set with fire, and another with ice 
Caliburni  ?  telegraphed line AoEs leaving swords that persist outside the arena. After a short time, the swords shoot back across 
Thermal Divide  450  Line and roomwide AoE; One side of the arena will be hit with fire, the other with ice. Stand OUTSIDE of the line telegraph, and on the side opposite of the buff you have. This will change your buff. 
Call Dimension Blade  n/a  Setup cast  nothing actually happens 
Solid Souls' Caliber  2000  pointblank AoE with late telegraph  get out; followed by arc or conal AoEs 
Empty Souls' Caliber  2000  donut AoE with late telegraph  get in; followed by arc or conal AoEs 
Vacuum Slash  2000  conal AoEs with Solid/Empty Souls' Caliber 
Frostforge  n/a  indicates Frost's Revelation will happen after next Souls' Caliber, so you'll need to get the fire buff 
Flameforge  n/a  indicates Flame's Revelation will happen after next Souls' Caliber, so you'll need to get the ice buff 
Frost's Revelation  250  roomwide iceaspected AoE  must have fire buff; switches your buff to ice 
Flame's Revelation  250  roomwide fireaspected AoE  must have ice buff; switches your buff to fire 
Exglacialis  ?  spawns 2 sets of 3 circle AoEs that turn into star AoEs. Outside the center ring of the arena, there is a pattern with 8 points. Each of these points is a safe spot for all possible patterns 
Exflammeus  400  spawns a series of circles that grow and explode; you can run clockwise around the boss's hitbox to avoid them 
Steel Strike (sword adds)  800  return attack from Caliburni swords (no element) 
Steel Flame (sword adds)  250  return attack from Caliburni swords (fire element) 
Steel Frost (sword adds)  250  return attack from Caliburni swords (ice element) 
Ice Bloom (star AoEs)  250  line AoEs from Exglacialis stars 
Notes:

Opening sequence:
 Paradoxum
 Caliburni  one set of blades
 Thermal Divide
 Blades from Caliburni fire back across the arena
 Call Dimensional Blade
 Solid OR Empty Souls' Caliber

Rotation after opening:
 Caliburni  3 sets of blades
 Paradoxum  one set of blades turns to fire, and another to ice
 Frostforge OR Flameforge  you'll need to make sure your buff is opposite of this
 Blades from Caliburni fire back across the arena. If you have the same element as the boss prepared, make sure to get hit by an opposite element blade
 Solid OR Empty Souls' Caliber
 Frost's OR Flame's Revelation, depending on which was prepared
 Exglacialis OR Exflammeus
 Thermal Divide
 Soul of Fire/Ice increases damage from the same element to 10x normal, so everything becomes a oneshot
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 5m30s with strength and Onion Knight (6.35)
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 6m45s with strength and Onion Knight (6.35)
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 17m45s with no offensive pomanders (6.35)
 8m30s with 1 strength, 1 dread, and Unei (6.35)
 6m45s with Onion Knight (6.35)
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 7m15s with strength and Onion Knight (6.35)
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